• The aim of the following work was

  2020-02-14

  

  The aim of the following work was to untap the potential of DIS as a low-cost substrate for fungal production of lignocellulolytic enzymes via SSF. Fungal strains with the ability to transform the unpretreated DIS to a mixture of industrially relevant lignocellulases were identified. Furthermore, th

• The glycolytic pathway is a catabolic route that

  2020-02-14

  

  The glycolytic pathway is a catabolic route that ends with the synthesis of pyruvate (Pyr). In Arabidopsis embryos, the conversion of phosphoenolpyruvate (PEP) to Pyr, catalyzed by pyruvate kinase (PK), is mainly located in the plastids [10], [11]. The preceding reaction is catalyzed by enolase (ENO

• br STAR Methods br Acknowledgments

  2020-02-13

  

  STAR★Methods Acknowledgments We thank Geneviève Almouzni, Sophie Polo, Ralph Scully, Wael Mansour, and Jeremy Stark for providing cell lines and Wolf Heyer, Haico van Attikum, Martijn Luijsterburg, and Brendan Price for helpful discussions. We thank Ratna Weimer, Bettina Basso, Christel Braun,

• MDL 28170 Acknowledgments br PGD is an aracha http www apexb

  2020-02-13

  

  Acknowledgments PGD is an arachadonic acid-derived prostaglandin produced in large quantities when asthmatic lung tissues are challenged by allergens. PGD contracts the airway tissue as well as stimulating an inflammatory response. PGD was also found to be the ligand for a second receptor, DP2 (

• The mechanisms in the central

  2020-02-13

  

  The mechanisms in the central nervous system (CNS) controlling the sympathetic tone of the h106 synthesis are associated to behavioral strategies, such as those involved in response to stress. In this regard, morphine withdrawal induces profound and severe stress reactions evidenced by enhancement

• In addition to carbamates organophosphates are classic inhib

  2020-02-13

  

  In addition to carbamates, organophosphates are classic inhibitors of cholinesterases. Previous studies with aquatic organisms have demonstrated their sensitivity to such chemicals. For example, individuals of the freshwater fish Colossoma macropomum exposed to the organophosphate dichlorvos, chlorp

• br Introduction The cys loop

  2020-02-13

  

  Introduction The cys-loop ligand gated ion channels (LGICs) are membrane-bound proteins mediating fast transduction from chemical to electrical signals at neuronal synapses and neuromuscular junctions [1], [2]. Each subunit that makes up the pentameric LGIC architecture possesses a dicysteine bri

• Q-VD(OMe)-OPh The estrogenic activity of steroids with a C m

  2020-02-13

  

  The estrogenic activity of steroids with a C19 methyl group may provide a selective advantage in estrogen physiology that is not provided by E2. In this regard, 5α-androstanediol has been proposed to be a second physiological estrogen in fetal mouse Q-VD(OMe)-OPh based on the timing of ERβ synthesis

• Introduction Ewing sarcomas primitive neuroectodermal tumors

  2020-02-13

  

  Introduction Ewing sarcomas/primitive neuroectodermal tumors (ES/PNETs) are relatively infrequent but the second most common sarcoma of the bone next to osteosarcoma. Nearly 80% of them occur in persons younger than 20years. Most of them arise from the bone, but 10 to 20% of them from soft tissue.

• Recently roflumilast has been approved as the first selectiv

  2020-02-13

  

  Recently, roflumilast has been approved as the first selective PDE4 inhibitor for the treatment of chronic obstructive pulmonary disease (COPD) [2]. Roflumilast has been suggested to target several different pathogenetic mechanisms, including inflammation, fibrotic, emphysematous and vascular remode

• The molecular mechanisms regulating the

  2020-02-13

  

  The molecular mechanisms regulating the differentiation of Th1 versus Tfh Trehalose from IL-12-stimulated CD4+ T cells remain largely uncharacterized in humans. This topic has been extensively studied in mice (Weinmann, 2014), because IL-12 stimulation promotes mouse naive CD4+ T cells to express bo

• br Materials and methods br Results br Discussion

  2020-02-13

  

  Materials and methods Results Discussion CDK and their regulatory cyclins form a family of heterodimeric kinases that are particularly important for regulation of OG-L002 progression and transcription in tumor cells. These kinases therefore constitute biomarkers of proliferation and attract

• COH inhibited global SUMOylation in cells

  2020-02-12

  

  COH000 inhibited global SUMOylation in 3466 and blocked the E1 catalyzed attachment of SUMO to the corresponding conjugating enzyme Ubc9, but not the attachment of ubiquitin or NEDD8 to their respective E2s, confirming inhibition and specificity in cellulo. Consistent with previous studies inactivat

• COH inhibited global SUMOylation in cells

  2020-02-12

  

  COH000 inhibited global SUMOylation in 3466 and blocked the E1 catalyzed attachment of SUMO to the corresponding conjugating enzyme Ubc9, but not the attachment of ubiquitin or NEDD8 to their respective E2s, confirming inhibition and specificity in cellulo. Consistent with previous studies inactivat

• COH inhibited global SUMOylation in cells

  2020-02-12

  

  COH000 inhibited global SUMOylation in 3466 and blocked the E1 catalyzed attachment of SUMO to the corresponding conjugating enzyme Ubc9, but not the attachment of ubiquitin or NEDD8 to their respective E2s, confirming inhibition and specificity in cellulo. Consistent with previous studies inactivat

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