• Curcumin is able to upregulate the protein level of NGF

  2023-08-17

  

  Curcumin is able to upregulate the protein level of NGF through cannabinoid receptor CB1, where the activation of Akt pathway probably plays an important part in the CB1-mediated signal transmission [9,10]. This finding suggested that the protection of curcumin in spinal motor neurons of SNI rats is

• br Results br Discussion Tapinarof GSK is

  2023-08-17

  

  Results Discussion Tapinarof (GSK2894512) is a naturally derived investigational topical medicine with demonstrated clinical efficacy for patients with AD and psoriasis (Bissonnette et al., 2010, Bissonnette et al., 2012a). The drug substance is a polyphenol produced by bacteria that is struct

• br Results br Discussion Dopamine regulates behavioral respo

  2023-08-17

  

  Results Discussion Dopamine regulates behavioral responses to nicotine in Drosophila (Bainton et al., 2000), but neurochemical measurements of dopamine after nicotine stimulation had not been made. Here, we demonstrate for the first time that the stimulation of nAChRs causes dopamine release i

• BCATc Inhibitor 2 Firms are subject to corporate

  2023-08-17

  

  Firms are subject to corporate taxation, and face either an ACE or a CBIT tax scheme. The two tax regimes achieve financing neutrality by treating debt and equity equally, but differ according to whether deduction of capital costs from the corporate tax BCATc Inhibitor 2 is allowed or not. While AC

• DBIBB br Conflict of interest statement br Benign prostatic

  2023-08-17

  

  Conflict of interest statement Benign prostatic hyperplasia (BPH) is a highly complex process characterized by an increased number of epithelial and stromal DBIBB in the transition zone. , , Autopsy studies by McNeal detail the evolution of histological changes within these 2 cellular compartme

• br The complementary role of chaperone mediated autophagy

  2023-08-17

  

  The complementary role of chaperone mediated autophagy Chaperone-mediated autophagy (CMA) mediates the degradation of specific cellular proteins and participates in the regulation of lipid metabolism, DNA repair, or the response to stress (Kaushik and Cuervo, 2018). CMA provides an alternative pa

• br Results and discussion br

  2023-08-17

  

  Results and discussion Conclusion A series of aminobenzothiazole derivatives were investigated as possible Aurora B kinase inhibitors. Bioisosteric replacement of the heterocyclic core of the lead compound was performed regarding the docking analysis. Replacement of the oxygen Santacruzamate A

• br Structure of V ATPase V ATPase is a

  2023-08-17

  

  Structure of V-ATPase V-ATPase is a highly conserved multi-subunit enzyme that uses energy from ATP hydrolysis to transport protons across membranes [2], [3], [4]. It consists of two major functional domains, V1 and V0 (Fig. 1). The former has eight different subunits (A, B, C, D, E, F, G, and H)

• In this study significant reduction

  2023-08-17

  

  In this study, significant reduction in the HCO3− content in sham-operated and testosterone-treated rats following bafilomycin A1 administration suggested that V-ATPase could be involved in mediating the decrease in vas deferens fluid HCO3− content, most probably due to the increase in H+ secretion

• A disruption of lung barrier function caused by

  2023-08-17

  

  A disruption of lung barrier function caused by PM2.5 has been observed in our experiments; however the underlying mechanism has not been investigated. Zhao et al. (2018) reported that PM2.5 down-regulated the expression levels of tight junction (TJ) proteins and resulted in nasal epithelial barrier

• In order to determine whether the faster Rh induced

  2023-08-17

  

  In order to determine whether the faster Rh2-induced apoptosis is specific of cholesterol depletion, we determined the cytotoxic effect of Rh2 in cgrp antagonist receptor depleted or not in sphingomyelin, another abundant plasma membrane lipid exhibiting enrichment in lipid rafts. We showed that, i

• IL-18, human recombinant protein Our previous studies and ot

  2023-08-17

  

  Our previous studies and others have identified that the inhalational anesthetic isoflurane induces neuronal apoptosis via [Ca2+]i overload through the opening of synaptic voltage-dependent calcium channels (VDCCs) and the excessive Ca2+ release from the endoplasmic reticulum (Zhao et al., 2011; Zha

• br Perspectives br Acknowledgments This investigation

  2023-08-16

  

  Perspectives Acknowledgments This investigation was supported by a Research Grant 2010/01385-5 from FAPESP (Sao Paulo Research Foundation, Brazil). P.F.S. was recipient of a CNPq (National Council for Scientific and Technological Development, Brazil) productivity grant. R.F.A. was recipient of

• br Materials and methods br Results br Discussion

  2023-08-16

  

  Materials and methods Results Discussion Prostate cancer is the most common cancer in men in the United States and the second leading cause of cancer death. Therapeutic interventions include mainly: radical prostatectomy or radiation therapy (RT), with or without androgen deprivation therap

• br Concluding Remarks and Future Perspectives While postmort

  2023-08-16

  

  Concluding Remarks and Future Perspectives While postmortem human hypoxia inducible factor material is relatively sparse and has inherent limitations as discussed above, additional investigations could benefit from analysis of in vitro cellular models to corroborate findings in patient material.

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