• A structural explanation for how RBR RING s handle

  2019-07-02

  

  A structural explanation for how RBR RING1s handle their bound E2~Ubs differently from canonical RINGs has not been readily apparent. Only a few residue positions are strongly conserved in RING and RING1 domains, most of which are zinc-coordinating Cys and histidine residues. A key position in canon

• Crystallographic and NMR based analyses have revealed that

  2019-07-02

  

  Crystallographic and NMR-based analyses have revealed that RINGs and U-boxes have a common mode of interaction with E2s (Fig. 2A). The key structural elements are two loop-like regions, which, in the case of RINGs, coordinate Zn. The loops surround a shallow groove formed by the central α-helix. Tog

• The E enzyme is the apex for downstream enzymatic

  2019-07-02

  

  The E1 enzyme is the apex for downstream enzymatic cascades and signaling pathways mediated by Ub and Ub-like proteins (Ubls) (Pickart, 2001). Studying characteristics of E1 and its catalytic functions may throw light to the role of ubiquitination in cell development. All known eukaryotic E1 are mon

• br Acknowledgments We thank all the ultramarathon runners

  2019-07-01

  

  Acknowledgments We thank all the ultramarathon runners who participated in this study and all the doctors, nurses, and emergency medical technicians who provided professional care at the ultramarathon race. We also thank our colleagues at Soochow University, Taipei, Taiwan and the Chinese Taipei

• tropisetron weight MADIT trial enrolled adult patients with

  2019-07-01

  

  MADIT trial enrolled 196 adult patients with prior myocardial infarction more than 3 weeks (Q wave or elevated cardiac enzyme), with non-sustained ventricular tachycardia (a run of 3–30 of ventricular ectopic beats with a rate more than 120 beats per minute), with left ventricular ejection fraction

• br Preoperative rehabilitation Severe pulmonary function

  2019-07-01

  

  Preoperative rehabilitation Severe pulmonary function impairment was considered inoperable in approximately 37% of patients with anatomically resectable lung cancer. The surgical morbidity and mortality rates for patients at an acceptable risk of perioperative complications were 31.6% and 4.3%, r

• The data also revealed notable differences in

  2019-07-01

  

  The data also revealed notable differences in practice patterns across the countries. In France, Italy, Spain and the UK, patients were most likely to have multiple disseminated sites of metastases at the time of initial bone DC260126 weight detection; however, patients in Germany were most likely t

• Based on these preliminary clinical results with

  2019-07-01

  

  Based on these preliminary clinical results with low-dose, intermittent zoledronic acid, Hu et al. conducted a randomized phase II clinical study in order to clarify the role of metronomic low-dose zoledronic acid. Sixty breast cancer patients with bone metastases were randomized to receive either 1

• In a recent study Nademanee et al reported additional eviden

  2019-07-01

  

  In a recent study, Nademanee et al. [76]. reported additional evidence pointing to pathologic changes in the RVOT of patients with BrS that have proved undetectable by echocardiography or MRI. In contrast, imaging techniques in ARVC clearly display morphologic and functional changes (e.g., dilation

• The strategy seeks to reduce preventable mortality This emph

  2019-07-01

  

  The 25×25 strategy seeks to reduce preventable mortality. This emphasis leads to the selection of the four disorders specified in the strategy (cardiovascular disease, diabetes, cancer, and chronic respiratory disease), which account for 87% of all deaths from NCDs (). However, when the burden of di

• The Millennium Development Goals MDGs have

  2019-07-01

  

  The Millennium Development Goals (MDGs) have become key targets for the international KPT-185 over the past 15 years. The MDGs have raised awareness, focused global efforts on agreed priorities, and empowered so-called development champions at country level. This progress was less straightforward th

• Importa notar al mismo tiempo cierta impaciencia

  2019-07-01

  

  Importa notar, al mismo tiempo, cierta impaciencia con la indeterminación del saber celebrada hasta no hace mucho. En la ruta hacia el neoliberalismo, ese tránsito del Estado al mercado —como suele llamársele en América Latina—, la duda epistémica, el pensamiento débil, los juegos de lenguaje y la r

• br Discussion IUI with controlled ovarian

  2019-06-29

  

  Discussion IUI with controlled ovarian hyperstimulation has been used over the years as a treatment for mild male factor, anovulation, and unexplained infertility. It is less expensive and less invasive than other assisted reproductive techniques. Therefore, these advantages have made the techniq

• Recogiendo en el cap tulo

  2019-06-29

  

  Recogiendo en el capítulo siguiente del libro (“La fenomenología del instante en ”, 147–161) lo que al final del anterior ha dicho sobre , Escalante propone, partiendo de la distinción entre descripción fenomenológica e interpretación, puesta, empero, en tela de juicio por Heidegger (148), que el “n

• Confluye aqu en su literalidad en

  2019-06-29

  

  Confluye aquí, en su literalidad, en su capacidad para evocar cierta “representación pura y simple de lo real”, esa retórica del cuerpo herpes simplex virus infection la que hice referencia más arriba. “Cuerpo-texto que destruye el cuerpo-carne pero se monta en él para transformarlo, para sustituirl

16142 records 1041/1077 page Previous Next First page 上5页 10411042104310441045 下5页 Last page